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Updated: Jul 10, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
Risk of cancer in an inbred population
Srdjan Denic1, Chris Frampton, M Gary Nicholls
1Department of Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, Abu Dhabi, United Arab Emirates s.denic@uaeu.ac.ae
Background:
In spite of a high prevalence of consanguineous marriages in Asia and Africa, there has been little epidemiological research on the effect of inbreeding on cancer risk.
Methods:
We conducted a case-control study of 391 native Arabs with cancer and 378 matched healthy controls. All cases had a histologic diagnosis of cancer. Participants were interviewed to collect information on the biological relatedness of their parents. Risk of cancer was determined in relation to the presence of parental consanguinity, coefficient of inbreeding (F), and whether subjects were more (F>or=0.0625) or less (F<0.0625) inbred, and was stratified by sex, age group, and cancer type.
Results:
Reduction of overall cancer risk was associated with increased F (P<0.001). In men, F was significantly higher in healthy controls than cancer patients overall (P=0.001) and in both younger (
Conclusions:
Inbreeding was associated with reduced overall risk of cancer in studied population. Reduction of cancer risk is greater in men than women and, in women, is restricted to those older than 30 years.
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