Related Experiment Video
Updated: Jul 10, 2026

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
Published on: June 13, 2017
Atropine autoinjector use as a suicidal gesture.
Charles L Taylor1, Shawn F Taylor
1Department of Emergency Medicine, Womack Army Medical Center, Fort Bragg, North Carolina, USA.
Military atropine autoinjectors, intended for nerve agent exposure, were misused in a suicide attempt. The patient developed an anticholinergic toxidrome but received successful treatment.
Area of Science:
- Toxicology
- Emergency Medicine
- Military Health
Background:
- Atropine autoinjectors are critical first-line medical countermeasures for U.S. military personnel against nerve agent exposure.
- These devices are designed for rapid, pre-hospital administration in combat or training scenarios.
Observation:
- A case report details the intentional misuse of atropine autoinjectors by an individual attempting suicide.
- The misuse led to the development of a severe anticholinergic toxidrome.
Findings:
- The patient presented with symptoms consistent with anticholinergic toxicity following self-administration of atropine.
- Prompt medical intervention and supportive care resulted in the successful recovery of the patient.
Implications:
- This case highlights the potential for misuse of readily available medical countermeasures.
- It underscores the importance of recognizing and managing anticholinergic toxidrome in emergency settings.
- Consideration of alternative indications and potential misuse scenarios for atropine autoinjectors may be warranted.
Related Concept Videos
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Depolarizing Blockers: Pharmocokinetics
Prevention of Further Absorption of Poison
Desensitization and Tachyphylaxis
Several...
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...

