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[Severe hypercalcemia due to vitamin D intoxication].

C Chambellan-Tison¹, B Horen, G Plat-Wilson

¹POSU pédiatrique, hôpital des enfants, CHU de Toulouse, 330, avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|October 13, 2007

Summary

Severe hypercalcemia in an infant was caused by vitamin D intoxication from excessive parental administration. Prompt treatment with hydration, diuretics, and biphosphonates led to full recovery, highlighting the risks of vitamin D overdose.

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Last Updated: Jul 10, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

Pediatric Endocrinology
Toxicology
Clinical Case Study

Background:

Vitamin D intoxication is a rare but serious condition in infants.
Excessive vitamin D supplementation can lead to severe hypercalcemia.
Cultural practices and internet accessibility of high-dose supplements contribute to this risk.

Observation:

A 4-month-old infant presented with anorexia, weakness, hypotonia, constipation, and lethargy.
Laboratory findings revealed severe hypercalcemia (4.28-4.55 mmol/l) and a short QTc interval on EKG.
The infant experienced neurological deterioration, requiring transfer to the pediatric intensive care unit.

Findings:

Diagnosis of vitamin D intoxication was confirmed due to excessive daily administration.
Treatment involved hyperhydration, loop diuretics, and sodium pamidronate infusion.
The infant developed nephrocalcinosis and iliac venous thrombosis but achieved full neurological recovery.

Implications:

Vitamin D intoxication should be considered in infants with hypercalcemia and neurological symptoms, especially those with a history of excessive supplementation.
Early diagnosis and appropriate management, including bisphosphonates, are crucial for favorable outcomes.
Awareness of the risks associated with high-dose vitamin D supplementation is essential for parents and healthcare providers.