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Related Experiment Videos

Photopheresis: a clinically relevant immunobiologic response modifier.

R L Edelson1

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510-8059.

Annals of the New York Academy of Sciences
|December 30, 1991
PubMed
Summary
This summary is machine-generated.

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Photopheresis using photoactivated 8-methoxypsoralen (8-MOP) effectively treats T cell disorders like cutaneous T cell lymphoma and autoimmune diseases. Its mechanism involves specific immunization against pathogenic T cells.

Area of Science:

  • Immunology
  • Dermatology
  • Oncology

Background:

  • Photopheresis is an extracorporeal treatment using photoactivated 8-methoxypsoralen (8-MOP).
  • It targets disorders involving aberrant T lymphocytes.

Purpose of the Study:

  • To evaluate the efficacy of photopheresis in various T cell-mediated disorders.
  • To explore the mechanism of action of photopheresis.

Main Methods:

  • Peripheral blood exposure to photoactivated 8-MOP in an extracorporeal system.
  • Observation of immunologic alterations and treatment outcomes in patients.

Main Results:

  • Photopheresis is standard for advanced cutaneous T cell lymphoma.
  • It shows promise for autoimmune disorders (pemphigus vulgaris, scleroderma, rheumatoid arthritis, lupus erythematosus) and transplant rejection.

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  • Preliminary trials initiated for multiple sclerosis, myasthenia gravis, and diabetes mellitus.
  • Less effective for B cell malignancies like chronic lymphocytic leukemia.

    • Conclusions:

    • Photopheresis is a versatile treatment for T cell-driven diseases.
    • The mechanism involves specific immunization against pathogenic T cells via photoactivated 8-MOP.
    • Further research is warranted for conditions like AIDS-related complex and other autoimmune diseases.