Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Factors Affecting Pulmonary Ventilation

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Longitudinal metabolomics profiles reveal increased gut microbial protein fermentation during Spaceflight.

Nature communications·2026

Same author

Long-term exposure to particulate matter from road traffic and residential heating and mortality: a multi-cohort study in Sweden.

Scientific reports·2026

Same author

Estimating the insulation health index of XLPE cables using machine learning.

Scientific reports·2025

Same author

Secondary organic aerosol in urban China: A distinct chemical regime for air pollution studies.

Science (New York, N.Y.)·2025

Same author

QC4Metabolomics: Real-Time and Retrospective Quality Control of Metabolomics Data.

Analytical chemistry·2025

Same author

The variability of selenium and sulphur and the impact of creatinine in blood and urine of humans.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2025

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

Indoor particles affect vascular function in the aged: an air filtration-based intervention study.

Elvira Vaclavik Bräuner¹, Lykke Forchhammer, Peter Møller

¹D. Institute of Public Health, Department of Environmental and Occupational Health, Øster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.

American Journal of Respiratory and Critical Care Medicine

|October 13, 2007

Summary

Reducing indoor air particles for 48 hours improved microvascular function (MVF) in healthy elderly individuals. This suggests indoor air filtration may be a feasible strategy to lower cardiovascular disease risk.

Related Experiment Videos

Last Updated: Jul 10, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

Area of Science:

Environmental Health
Cardiovascular Research
Gerontology

Background:

Particulate matter exposure is linked to cardiovascular events, potentially via endothelial dysfunction.
Indoor air quality is a significant factor in particulate matter exposure.

Purpose of the Study:

To investigate the effects of controlled indoor air particle exposure on microvascular function (MVF) in healthy elderly individuals.
To assess changes in biomarkers of inflammation and oxidative stress as secondary endpoints.

Main Methods:

A randomized, double-blind, crossover study involving 21 couples exposed to filtered or non-filtered indoor air for 48 hours.
Microvascular function (MVF) assessed noninvasively via digital peripheral artery tone.
Secondary endpoints included various blood biomarkers, coagulation factors, and blood pressure.

Main Results:

Indoor air filtration significantly improved MVF by 8.1% (95% CI, 0.4-16.3%).
Particulate matter mass (diameter < 2.5 µm) was more critical than particle number concentration (10-700 nm).
No significant changes were observed in secondary biomarkers after Bonferroni correction.

Conclusions:

A short 48-hour reduction in indoor particle exposure via filtration improved MVF in healthy elderly participants.
Indoor air filtration presents a potentially feasible method for mitigating cardiovascular disease risk.