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Penetration of antibiotics through omiderm in vitro and on split-thickness skin grafts in burn patients

J M Russavage1, H Slater, I W Goldfarb

  • 1General Surgery Department, University of Pittsburgh, Presbyterian University Hospital, PA.

Annals of Plastic Surgery
|December 1, 1991
PubMed

Insights

Antibiotic preparations effectively penetrate Omiderm, a synthetic wound covering. This synthetic dressing does not impede the antimicrobial activity of gentamicin, neomycin, silver sulfadiazine, and mupirocin.

Area of Science:

  • Wound healing research
  • Dermatology
  • Infectious disease

Background:

  • Synthetic wound coverings are crucial for managing burns.
  • Assessing the compatibility of topical antimicrobials with wound dressings is essential for effective burn treatment.
  • Omiderm is a synthetic wound covering used in burn management.

Purpose of the Study:

  • To evaluate the penetration of common antibiotic preparations through Omiderm.
  • To determine if Omiderm affects the antimicrobial efficacy of these preparations.

Main Methods:

  • In vitro testing of antibiotic penetration through Omiderm (meshed and unmeshed).
  • Clinical evaluation in 5 patients with full-thickness burns treated with Omiderm and skin grafting.
  • Antimicrobial activity assessed via zones of inhibition compared to controls.

Main Results:

  • All tested antibiotic preparations (gentamicin, neomycin, silver sulfadiazine, mupirocin) demonstrated penetration through both meshed and unmeshed Omiderm.
  • Omiderm did not alter the antimicrobial activity zones of inhibition for the tested antibiotics.

Conclusions:

  • Omiderm allows penetration of key antibiotic preparations.
  • The use of Omiderm as a wound covering does not compromise the antimicrobial efficacy of commonly used topical antibiotics.

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