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Published on: October 5, 2015
Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosis
S Prabhu Anand1, P Selvaraj, M S Jawahar
1Tuberculosis Research Centre (ICMR), Chennai, India.
The Indian Journal of Medical Research
|October 13, 2007
Summary
Interleukin-10 and Interleukin-12B gene polymorphisms do not influence susceptibility to pulmonary tuberculosis. This study found no significant association between these cytokine gene variations and tuberculosis risk in the South Indian population.
Area of Science:
- Immunogenetics
- Molecular Epidemiology
- Tuberculosis Research
Background:
- Cytokines are crucial in anti-tuberculosis immunity, with potential shifts from protective to pathogenic responses.
- Cytokine gene polymorphisms can alter immune regulation and disease outcomes.
- Investigating specific polymorphisms like Interleukin-10 (-1082 G/A) and Interleukin-12B 3' UTR (Taq1) (A/C) is important for understanding tuberculosis susceptibility.
Purpose of the Study:
- To determine if Interleukin-10 (-1082 G/A) and Interleukin-12B 3' UTR (Taq1) (A/C) gene polymorphisms are associated with pulmonary tuberculosis susceptibility.
- To explore the role of specific cytokine gene variations in the immune response to tuberculosis.
Main Methods:
- A case-control study involving 132 pulmonary tuberculosis patients and 143 healthy controls from South India.
- DNA analysis using polymerase chain reaction (PCR) with sequence-specific primers and restriction digestion to genotype IL-10 and IL-12B gene polymorphisms.
Main Results:
- No significant differences were observed in the allelic or genotypic frequencies of Interleukin-10 (-1082) and Interleukin-12B (3'UTR Taq 1) between pulmonary tuberculosis patients and healthy controls.
- The distribution of IL-10 and IL-12B gene variants was similar in both groups.
Conclusions:
- The studied Interleukin-10 (-1082 G/A) and Interleukin-12B 3'UTR (Taq I) (A/C) gene polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in the South Indian population.
- These specific cytokine gene variations do not appear to be major genetic risk factors for pulmonary tuberculosis in this demographic.
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