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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
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Hydatid disease in Iranian children

Setareh Mamishi1, Setareh Sagheb, Babak Pourakbari

  • 1Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. smamishi@sina.tums.ac.ir

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|October 13, 2007
PubMed

Insights

Pediatric hydatidosis is endemic in Iran, frequently affecting lungs and liver. Early diagnosis and treatment, including surgery and albendazole, are crucial for managing this public health concern.

Area of Science:

  • Parasitology
  • Public Health
  • Pediatric Medicine

Background:

  • Hydatidosis poses a significant public health challenge, causing considerable morbidity and mortality.
  • Control and eradication strategies are feasible.
  • This study focuses on pediatric hydatidosis in Iran.

Purpose of the Study:

  • To investigate the characteristics of pediatric hydatidosis in Iran.
  • To analyze demographic, clinical, and therapeutic aspects of the disease in children.

Main Methods:

  • Retrospective analysis of 31 pediatric patients diagnosed with hydatidosis.
  • Data collected from 1995-2005 at Children Medical Center Hospital, Tehran.
  • Inclusion of demographic, clinical, cyst location, laboratory, and treatment data.

Main Results:

  • The study included 18 males (58%) and 13 females (42%), with a mean age of 8.3 years.
  • Pulmonary and hepatic cysts were most common (77% and 48%), with 26% having both.
  • Common symptoms included cough (92%), fever (83%), and dyspnea (46%) for pulmonary cysts; fever (100%) and hepatomegaly (87%) for hepatic cysts.

Conclusions:

  • Hydatidosis is endemic in Iran, necessitating suspicion in children with relevant exposure history.
  • Clinical presentation varies by cyst location, with lung and liver involvement being most frequent.
  • Surgical intervention and albendazole treatment showed a low recurrence rate (6%).
Abstract

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