Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multifunctional nanoparticulate polyelectrolyte complexes.

Sean M Hartig1, Rachel R Greene, Jayasri DasGupta

  • 1Divison of Pediatrics Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.

Pharmaceutical Research
|October 13, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2026
Same author

NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription.

Science advances·2026
Same author

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways.

bioRxiv : the preprint server for biology·2026
Same author

Toward Scientific Rigor: Setting Standards for Indirect Calorimetry Analysis and Reporting.

Diabetes·2025
Same author

A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility.

Endocrinology·2025
Same author

A consensus guide to preclinical indirect calorimetry experiments.

Nature metabolism·2025
Same journal

Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma.

Pharmaceutical research·2026
Same journal

Impact of Febrile State on Vancomycin Clearance in Pediatric Patients: Insights From Population Pharmacokinetic Modeling.

Pharmaceutical research·2026
Same journal

Sustained Intra-Articular Delivery of Triple Therapeutics Using a Phase-Transition Phospholipid-Based Gel for Effective Treatment of Gouty Arthritis.

Pharmaceutical research·2026
Same journal

Spray Dried Lysozyme Microspheres: Morphological Evolution and Enzymatic Activity Retention.

Pharmaceutical research·2026
Same journal

Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer.

Pharmaceutical research·2026
Same journal

Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties.

Pharmaceutical research·2026
See all related articles

Biodegradable polyelectrolyte complex dispersions (PECs) offer safer drug delivery systems. These nanoparticles show promise for targeted delivery and imaging applications in humans.

Area of Science:

  • Polymer Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Current drug delivery systems face limitations due to toxicity.
  • Water-soluble, biodegradable polymeric polyelectrolyte complex dispersions (PECs) have emerged as a safer alternative.
  • These aqueous nanoparticulate architectures are advantageous for human applications.

Purpose of the Study:

  • To review the development of polyelectrolyte complex dispersions (PECs).
  • To explore the potential applications of PECs in drug/gene delivery and imaging.
  • To highlight PECs as multi-functional, site-specific nanoparticulate delivery devices.

Main Methods:

  • PECs are formed by mixing oppositely charged polyions.
  • Key characteristics like hydrodynamic diameter, surface charge, and polydispersity are influenced by concentration, ionic strength, pH, and polymer molecular parameters.

Related Experiment Videos

  • Formation of water-insoluble aggregates can occur with polymers of significantly different molecular weights.

    • Main Results:

    • Favorable PEC characteristics for cellular uptake and colloidal stability include hydrodynamic diameter < 200 nm, surface charge > ±30 mV, spherical morphology, and low polydispersity index (PDI).
    • Maintaining these properties is crucial for effective delivery vehicles.
    • The review focuses on PECs with potential for multi-functional, site-specific delivery and imaging.

    Conclusions:

    • Polyelectrolyte complex dispersions (PECs) represent a promising advancement in drug delivery technology.
    • Their tunable properties and biodegradability offer significant advantages over existing systems.
    • Further development of PECs could lead to innovative therapeutic and diagnostic tools.