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Published on: November 27, 2019
Captopril and lisinopril decrease acetaldehyde effects upon the prothrombin time.
Arthur S Brecher1, Rachel Dubord
1Department of Chemistry, Bowling Green State University, Bowling Green, OH 43403, USA. artbrec@bgsu.edu
Digestive Diseases and Sciences
|October 13, 2007
Summary
Captopril and lisinopril, used to treat hypertension, may reduce the blood clotting effects of acetaldehyde, a byproduct of alcohol metabolism. This interaction suggests these drugs could potentially mitigate alcohol
Area of Science:
- Pharmacology
- Biochemistry
- Hematology
Background:
- Antihypertensive drugs captopril (thiol-containing) and lisinopril (amino-containing) prolong prothrombin time (PT).
- Acetaldehyde, a metabolite of ethanol, also prolongs PT.
- Alcoholism and hypertension can impact hemostasis.
Purpose of the Study:
- To investigate the interrelationship between hypertension, hemostasis, and alcoholism.
- To examine the impact of acetaldehyde on the effects of captopril and lisinopril on PT.
Main Methods:
- Plasma samples were treated with captopril and/or acetaldehyde, or lisinopril and/or acetaldehyde.
- Prothrombin time (PT) was measured to assess clotting effects.
Main Results:
- Pre-mixing or sequential addition of captopril with acetaldehyde resulted in a lesser PT prolongation than acetaldehyde alone.
- Pre-mixing or sequential addition of lisinopril with acetaldehyde also resulted in a lesser PT prolongation than acetaldehyde alone.
- Captopril may form a thiohemiacetal with acetaldehyde, and may prolong PT by reducing S-S bridges in coagulation factors.
- Lisinopril may form Schiff bases with acetaldehyde.
Conclusions:
- Both captopril and lisinopril appear to partially inactivate or detoxify the hemostatic effects of acetaldehyde.
- Captopril and lisinopril may mitigate the impact of acetaldehyde on plasma clotting through different chemical mechanisms.
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