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Scaling from discs to pleated devices.

Sal Giglia1, David Yavorsky

  • 1Millipore Corporation, Ashby Road, Bedford MA 01730, USA. sal_giglia@millipore.com

PDA Journal of Pharmaceutical Science and Technology
|October 16, 2007
PubMed
Summary

Predicting sterilizing-grade membrane filter performance from discs to cartridges is possible by accounting for device parameters. Throughput scalability factors approach unity, especially with fouling, indicating reliable performance prediction.

Area of Science:

  • Filtration Science
  • Chemical Engineering
  • Materials Science

Background:

  • Membrane discs are standard for evaluating filtration performance.
  • Pleated filter devices and discs exhibit different scaling behaviors.
  • Understanding scalability is crucial for accurate filter performance prediction.

Purpose of the Study:

  • Quantify performance differences in sterilizing-grade membrane filters.
  • Investigate factors influencing device scalability.
  • Develop a mathematical model for cartridge-to-disc scalability prediction.

Main Methods:

  • Measured and predicted normalized water permeability scalability factors.
  • Evaluated seven types of pleated cartridges (PES, PVDF) in various lengths.

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  • Conducted throughput tests with diverse challenge streams and fouling characteristics.

    • Main Results:

    • Pleated cartridge performance closely predicted from disc data with parameter accounting.
    • Parasitic losses, membrane variability, effective area, and support properties are key factors.
    • Throughput scalability factors converged towards unity, especially for fouling streams, within +/-10% of 1.0.

    Conclusions:

    • Accurate prediction of filter performance from discs to cartridges is achievable.
    • Fouling significantly impacts scalability, driving factors towards unity.
    • Pressure and temperature showed no significant effect on scalability.