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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Aminocarbonylation route to tolvaptan

Yasuhiro Torisawa1, Takuya Furuta, Takao Nishi

  • 1Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Naka-Orui, Takasaki, Gunma 370-0033, Japan. torisawa@takasaki-u.ac.jp

Bioorganic & Medicinal Chemistry Letters
|October 16, 2007
PubMed
Summary

A new palladium-catalyzed reaction efficiently synthesizes a key intermediate for tolvaptan, a drug used to treat hyponatremia. This one-step process improves the synthesis of this important pharmaceutical compound.

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