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Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives
A Alivert1, F Canals, J J Bonet
1C.E.T.S. Institut Químic de Sarrià, Department of Organic Chemistry, Barcelona, Spain.
Archiv Der Pharmazie
|September 1, 1991
Abstract:
The synthesis and preliminary assays as hypocholesterolemic agents of five N-diphenylmethylpiperazines are described. The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chlorosubstituted compounds showed higher activity than their corresponding dechlorinated analogs.