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Related Experiment Video

Updated: Jul 10, 2026

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Plasmodium malariae: parasite and disease.

William E Collins¹, Geoffrey M Jeffery

¹Centers for Disease Control and Prevention, National Center for Zoonotic, Vector Borne and Enteric Diseases, Division of Parasitic Diseases, Chamblee, GA 30341, USA. wec1@cdc.gov

Clinical Microbiology Reviews

|October 16, 2007

Summary

Plasmodium malariae, the quartan malaria parasite, has a complex life cycle. Studies reveal its infection dynamics in humans and its adaptation to infect monkeys, causing kidney pathology in both.

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Area of Science:

Medical Parasitology
Infectious Diseases
Immunology

Background:

Plasmodium malariae is the causative agent of quartan malaria in humans.
Historical data from malaria therapy for neurosyphilis provides insights into P. malariae infections.
Kidney pathology, including nephrotic syndrome, is a known complication of P. malariae infection.

Purpose of the Study:

To review the life history of Plasmodium malariae.
To present data on prepatent periods, fever episodes, and parasitemia.
To discuss vectors and host-parasite interactions, including zoonotic potential.

Main Methods:

Review of historical clinical data from induced human infections (1940-1963).
Analysis of experimental infections in non-human primates (chimpanzees, monkeys).
Discussion of known and experimental vectors of Plasmodium malariae.

Main Results:

Detailed data on prepatent periods, fever, and parasitemia in human infections.
Experimental infections readily established in splenectomized chimpanzees and New World monkeys.
Plasmodium brasilianum in South American monkeys is likely an adapted form of P. malariae.
Monkey models exhibit similar kidney pathology (glomerular basement membrane thickening, endocapillary proliferation) as seen in human infections.

Conclusions:

Plasmodium malariae exhibits distinct infection characteristics in humans.
Non-human primates serve as valuable models for studying P. malariae.
Plasmodium malariae has likely adapted to infect monkeys, representing a recent zoonotic event.
The pathology observed in infected monkeys mirrors human kidney disease, validating their use in research.