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Ehlers-Danlos type IV in pregnancy. A case report and a literature review

Y Erez1, Y Ezra, N Rojansky

  • 1Department of Obstetrics and Gynecology, Hadassah Medical Center, Ein-Kerem, Jerusalem, Israel.

Fetal Diagnosis and Therapy
|October 16, 2007
PubMed

Insights

Pregnant individuals with Ehlers-Danlos syndrome type IV, a collagen disorder, face significant risks. Early cesarean delivery is recommended for a safe outcome in vascular Ehlers-Danlos syndrome.

Area of Science:

  • Obstetrics and Gynecology
  • Genetics
  • Vascular Medicine

Background:

  • Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders impacting collagen synthesis.
  • Vascular EDS (EDS type IV) is the most severe subtype, increasing risks of arterial and organ rupture.
  • Obstetrical complications in EDS type IV include uterine rupture, perineal trauma, and postpartum hemorrhage.

Observation:

  • A case report details a primigravida diagnosed with Ehlers-Danlos syndrome type IV.
  • The patient underwent a successful cesarean section at 36 weeks of gestation.
  • The postpartum recovery was uneventful.

Findings:

  • Cesarean delivery at 36 weeks gestation resulted in a successful maternal and fetal outcome.
  • The patient experienced no significant complications during or after the procedure.

Implications:

  • Early, planned cesarean delivery appears to be a safe and effective management strategy for pregnant individuals with EDS type IV.
  • This approach may mitigate the risks of severe obstetric and vascular complications associated with vascular Ehlers-Danlos syndrome.
  • Further research and case studies are warranted to solidify optimal management protocols for EDS in pregnancy.
Abstract

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