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Updated: Jul 10, 2026

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data
Published on: December 15, 2023
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Sandip Ray1, Markus Britschgi, Charles Herbert
1Satoris, Inc., 2686 Middlefield Road, Suite E, Redwood City, California 94063, USA.
Abstract:
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
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