Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased plasma immunoreactive endothelin-1 concentration in hypercholesterolemic rats.

T Horio1, M Kohno, K Murakawa

  • 1First Department of Internal Medicine, Osaka City University Medical School, Japan.

Atherosclerosis
|August 1, 1991
PubMed
Summary

Hypercholesterolemia, or high cholesterol, significantly elevates plasma endothelin-1 levels in rats. This increase in endothelin-1 may contribute to the development of atherosclerotic vascular lesions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new SOBP-formation method by superposing specially shaped Bragg curves formed by a mini-ridge filter for spot scanning in proton beam therapy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2019
Same author

Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol.

Psychopharmacology·2016
Same author

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours.

British journal of cancer·2011
Same author

Optical wave-front transformer using the multiple-reflection interference effect inside a resonator.

Optics letters·2008
Same author

The change in zoster-associated pain treated with oral valaciclovir in immunocompetent patients with acute herpes zoster.

International journal of clinical practice·2007
Same author

Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients.

Journal of human hypertension·2006

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Biochemistry

Background:

  • Hypercholesterolemia is a significant risk factor for cardiovascular diseases.
  • Endothelin-1 is a potent vasoconstrictor implicated in vascular pathology.

Purpose of the Study:

  • To investigate the relationship between hypercholesterolemia and plasma endothelin-1 levels.
  • To assess the impact of hypercholesterolemia on aortic morphology in rats.

Main Methods:

  • Rats were fed standard, high-cholesterol, or high-cholesterol plus clinofibrate diets for 4 and 8 weeks.
  • Plasma levels of endothelin-1, total cholesterol, triglycerides, and lipoproteins were measured.
  • Aortic tissues were examined for morphological changes.

Related Experiment Videos

Main Results:

  • High cholesterol diet significantly increased plasma total cholesterol, LDL, VLDL, and endothelin-1 levels.
  • Clinofibrate treatment reduced these lipid parameters and endothelin-1 levels.
  • Plasma endothelin-1 concentration correlated positively with total cholesterol, LDL, and VLDL levels.

Conclusions:

  • Hypercholesterolemia, even without atherosclerosis, elevates plasma endothelin-1 in rats.
  • Increased endothelin-1 associated with hypercholesterolemia may initiate or promote atherosclerotic vascular lesions.