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Related Experiment Video

Updated: Jul 10, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation.

L Bashoura¹, S Gupta, A Jain

¹Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. lbashoura@mdanderson.org

Bone Marrow Transplantation

|October 16, 2007

Summary

High-dose inhaled corticosteroids may effectively treat post-transplantation constrictive bronchiolitis (PTCB), a common complication after allogeneic hematopoietic stem cell transplantation (HSCT). This treatment stabilized lung function in patients with PTCB.

Related Experiment Videos

Last Updated: Jul 10, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Area of Science:

Pulmonology
Hematology
Immunology

Background:

Post-transplantation constrictive bronchiolitis (PTCB) is a frequent pulmonary complication in allogeneic hematopoietic stem cell transplantation (HSCT) survivors.
PTCB is a late manifestation of graft-versus-host disease (GVHD) and its current treatment with systemic corticosteroids has significant side effects.
Topical corticosteroids are used for other GVHD manifestations to mitigate systemic side effects.

Purpose of the Study:

To evaluate the efficacy of high-dose inhaled corticosteroids for treating PTCB.
To assess the impact of inhaled corticosteroids on airflow obstruction in PTCB patients.

Main Methods:

Retrospective analysis of adult patients diagnosed with new-onset PTCB.
Patients received high-dose inhaled fluticasone propionate (500-940 mcg BID).
Forced expiratory volume in 1 second (FEV1) was monitored before and after treatment.

Main Results:

Seventeen patients with PTCB showed a significant decline in FEV1 post-HSCT (median 53%).
Treatment with inhaled corticosteroids led to improvement in airway obstruction symptoms.
FEV1 stabilized in patients 3-6 months after initiating inhaled corticosteroid therapy.

Conclusions:

High-dose inhaled corticosteroids demonstrate potential efficacy in treating PTCB.
Inhaled corticosteroids may offer a localized treatment option with potentially fewer side effects than systemic regimens.
Further prospective studies are warranted to confirm the efficacy of inhaled corticosteroids for PTCB.