Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does acute hyperglycemia alter rat aortic depressor nerve function?

D A Huber1, J M do Carmo, J A Castania

  • 1Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|October 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of autonomic effects of ketamine-xylazine in normotensive and hypertensive rats.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica·2025
Same author

Impact of angiotensin-converting enzyme inhibition on hemodynamic and autonomic profile of elastase-2 knockout mice.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2022
Same author

Effects of exercise training on autonomic modulation and mood symptoms in patients with obstructive sleep apnea.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2021
Same author

The α2,3-selective potentiator of GABA<sub>A</sub> receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.

Pharmacology, biochemistry, and behavior·2019
Same author

Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex.

Molecular neurobiology·2018
Same author

Effect of different anesthetic agents on left ventricular systolic function assessed by echocardiography in hamsters.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2016
Same journal

RETRACTION: NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Comparison of two treatments for dry eye disease after corneal refractive surgery.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

COVID-19 mortality risk among women with ovarian cancer: a matched case-control study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
See all related articles

Short-term hyperglycemia does not affect aortic depressor nerve activity in rats. This study investigated the impact of high blood glucose on baroreflex function, finding no significant alterations in nerve activity.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Neuroscience

Background:

  • Hyperglycemia's effect on baroreflex function is not fully understood.
  • The specific site within the reflex arc (afferent, central, or efferent) affected by hyperglycemia remains unclear.

Purpose of the Study:

  • To investigate the impact of short-term hyperglycemia on aortic depressor nerve function.
  • To determine if hyperglycemia alters baroreflex sensitivity at the afferent or efferent limb.

Main Methods:

  • Utilized anesthetized male Wistar rats, divided into glucose, saline, and mannitol infusion groups.
  • Assessed aortic depressor nerve function using mean arterial pressure vs. nerve activity curves and cross-spectral analysis.
  • Induced arterial pressure oscillations via controlled bleeding for transfer function magnitude calculation.

Related Experiment Videos

Main Results:

  • Glucose infusion significantly increased blood glucose and plasma osmolarity.
  • Mean arterial pressure remained unchanged across all groups.
  • Both mean arterial pressure vs. nerve activity curves and transfer function magnitude showed no significant alterations due to hyperglycemia.

Conclusions:

  • Short-term hyperglycemia (30 minutes) does not impair aortic depressor nerve activity.
  • Baroreceptor reflex function, assessed via two distinct methods, is not affected by acute high blood glucose levels.