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Updated: Jul 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
[Therapeutical approach of obesity in Prader-Willi Syndrome]
Daniel F de Carvalho1, Cíntia Cercato, Madson Q Almeida
1Grupo de Obesidade e Síndrome Metabólica, Divisão de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, SP.
Abstract:
Prader-Willi Syndrome (PWS) is a multisystemic genetic disease characterized by hypotonia, mental retardation, characteristic facial appearance, hyperphagia, and compulsive eating due to hypothalamic dysfunction. PWS is caused by loss of function of genes located in chromosome 15q11-q13, an area subject to genomic imprinting. Obesity is a major cause of increased morbidity and mortality among patients with PWS. The objective of this study was to analyze the therapeutic options available for the treatment of the obesity in PWS including pharmacological and surgical strategies.
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