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Updated: Jul 10, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Current strategies for ischemic stroke prevention: role of multimodal combination therapies
1Dept. of Neurology, Northwestern University, Feinberg School of Medicine, 710 North Lake Shore Drive, Room 1420, Chicago, IL 60611, USA. m-alberts@northwestern.edu
Insights
Stroke is a leading cause of death and disability, necessitating better treatments. Secondary stroke prevention strategies, including antiplatelet therapies, are crucial for reducing recurrent ischemic events.
Area of Science:
- Neurology
- Cardiology
- Vascular Medicine
Background:
- Stroke is a primary cause of mortality and long-term disability worldwide.
- Ischemic strokes, often due to atherothrombosis or cardioembolism, pose significant health challenges.
- Patients with stroke face elevated risks of recurrent ischemic events across cerebral, coronary, and peripheral vascular territories.
Purpose of the Study:
- To emphasize the critical role of stroke prevention in managing ischemic stroke.
- To highlight the importance of a continuum of care, initiating interventions during hospitalization and continuing outpatient management.
- To discuss various therapeutic approaches for secondary stroke prevention.
Main Methods:
- Review of current therapeutic strategies for secondary stroke prevention.
- Discussion of pharmacotherapy, lifestyle adjustments, anticoagulants, and antiplatelet agents.
- Emphasis on the integration of preventive measures within acute hospitalization and outpatient settings.
Main Results:
- Antiplatelet therapies are fundamental to secondary stroke prevention.
- Management of modifiable risk factors (hypertension, dyslipidemia, smoking) is essential.
- A coordinated continuum of care is vital for preventing recurrent ischemic strokes.
Conclusions:
- Effective stroke prevention is paramount due to limited acute treatment options.
- Comprehensive management, including risk factor control and antiplatelet therapy, is key.
- Initiating and maintaining preventive interventions during and after hospitalization improves patient outcomes.
Abstract:
Stroke remains a global leading cause of death and long-term disability, highlighting the need for more effective treatment approaches. The majority of strokes are of ischemic origin, often caused by large- or small-artery atherothrombosis, or cardioembolism. Considering the systemic nature of the atherothrombotic disease process, stroke patients are at increased risk for ischemic events in several vascular territories: cerebral, coronary and peripheral. Due to the limited options for acute stroke therapies, stroke prevention is an important therapeutic approach. In addition to the management of modifiable risk factors such as hypertension, dyslipidemia and smoking through pharmacotherapy or lifestyle adjustments, anticoagulants, surgical and perhaps endovascular approaches are indicated in certain patients. Antiplatelet therapies using various agents are a cornerstone of secondary stroke prevention. To ensure the appropriate continuum of care after hospitalization for ischemic stroke, some interventions for the prevention of recurrent ischemic stroke should be initiated during the acute hospitalization setting and maintained in the out-patient setting.
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