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Exploring a nanotube dispersion mechanism with gold-labeled proteins via cryo-TEM imaging

Pola Goldberg-Oppenheimer1, Oren Regev

  • 1Department of Chemical Engineering, The Ilse Katz Center for Meso and Nanoscale Science and Technology, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.

Small (Weinheim an Der Bergstrasse, Germany)
|October 16, 2007
PubMed
Abstract

No abstract available in PubMed .

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...