Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The IKKα-regulated microRNA miR-9-5p mediates lung cancer growth and invasiveness via CDH1/Wnt/β-catenin signalling.

Cell death discovery·2026
Same author

Updated ENIGMA recommendations for reporting germline variants in cancer susceptibility genes and their translation into twenty languages.

Journal of medical genetics·2026
Same author

Dedifferentiated Cervical Mesonephric Adenocarcinoma: Report of 2 Cases of a Previously Undescribed Phenomenon.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists·2025
Same author

ASTRA: a comprehensive resource of stress-induced transcriptional activity in human cell lines.

Nucleic acids research·2025
Same author

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.

NPJ genomic medicine·2025
Same author

Spatiotemporal Dynamics of Microbial and Fish Communities in the Thracian Sea Revealed by eDNA Metabarcoding.

Microorganisms·2025

Related Experiment Video

Updated: Jul 10, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Hereditary cancer syndromes.

Florentia Fostira1, Georgia Thodi, Irene Konstantopoulou

  • 1Molecular Diagnostics Laboratory, I/RRP, National Centre for Scientific Research Demokritos, Athens, Greece.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|November 6, 2007
PubMed
Summary

Understanding inherited cancer syndromes like HNPCC, FAP, and HBOC is crucial. Genetic testing aids in early diagnosis and management of hereditary cancer risks for patients and families.

More Related Videos

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Related Experiment Videos

Last Updated: Jul 10, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Inherited cancer syndromes are characterized by specific susceptibility genes.
  • Family studies reveal distinct phenotypical features, age of onset, and survival rates.
  • Advances include identifying moderate-risk genes interacting with environmental factors.

Purpose of the Study:

  • To review characteristic hereditary cancer syndromes.
  • To focus on Hereditary Non-Polyposis Colorectal Cancer (HNPCC), Familial Adenomatous Polyposis (FAP), and Hereditary Breast/Ovarian Cancer (HBOC).
  • To highlight the genetic basis and clinical implications of these syndromes.

Main Methods:

  • Literature review of hereditary cancer syndromes.
  • Focus on genetic mutations in MMR genes (MLH1, MSH2, MSH6) for HNPCC.
  • Analysis of APC gene mutations for FAP and BRCA1/BRCA2 mutations for HBOC.

Main Results:

  • HNPCC is linked to mismatch repair gene mutations.
  • FAP is associated with APC gene mutations.
  • HBOC is linked to BRCA1 and BRCA2 gene mutations.

Conclusions:

  • Genetic testing is vital for primary healthcare, impacting patient quality of life and enabling early diagnosis for relatives.
  • Understanding these syndromes improves cancer predisposition assessment.
  • Molecular basis of hereditary cancer is increasingly understood through genetic research.