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Updated: Jul 10, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis of benzyl esters using 2-benzyloxy-1-methylpyridinium triflate
Jumreang Tummatorn1, Philip A Albiniak, Gregory B Dudley
1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA.
Abstract:
Triethylamine (Et3N) mediates esterification reactions between the title reagent (1) and carboxylic acids. Alcohols, phenols, amides, and other sensitive functionality are not affected; a dual role for Et3N as a promoter and a scavenger is postulated. Benzyl esters are obtained from substrates including amino acid and sugar derivatives.
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