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Related Experiment Video

Updated: Jul 10, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Neuropathic changes in equine laminitis pain.

Emma Jones¹, Ignacio Viñuela-Fernandez, Rachel A Eager

¹Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, R(D)SVS, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, United Kingdom Division of Veterinary Clinical Sciences, R(D)SVS, The University of Edinburgh, Roslin, Midlothian EH25 9RG, United Kingdom.

|October 16, 2007

Summary

Equine laminitis pain may stem from nerve damage, not just inflammation. This study found nerve changes in laminitic horses, suggesting anti-neuropathic drugs could help manage this debilitating condition.

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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Area of Science:

Veterinary Science
Equine Medicine
Neurology

Background:

Laminitis is a painful equine disease causing hoof lamellar disruption.
Conventional pain relief is often ineffective, leading to severe pain and euthanasia.
Understanding laminitis pain mechanisms is crucial for effective treatment.

Purpose of the Study:

To investigate the underlying mechanisms of pain in equine laminitis.
To examine peripheral nerve changes and neuronal markers in laminitic horses.
To determine if laminitis involves a neuropathic pain component.

Main Methods:

Quantified behavioral pain indicators in laminitic and normal horses.
Performed electron microscopy on digital nerves of laminitic horses.
Analyzed expression of neuronal injury markers (ATF3) and neuropeptides (NPY) in dorsal root ganglia (DRG).

Main Results:

Laminitic horses exhibited abnormal behaviors indicative of pain.
Digital nerves showed abnormal morphology with reduced myelinated and unmyelinated fibers.
Upregulated ATF3 and increased NPY expression were found in C8 DRG neurons, consistent with neuropathic pain.

Conclusions:

Equine laminitis involves a neuropathic pain component, evidenced by peripheral nerve and DRG changes.
These findings suggest that therapies targeting neuropathic pain may be beneficial for laminitis management.
Further research into anti-neuropathic analgesics for horses is warranted.