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Related Experiment Video

Updated: Jul 10, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

[Necrotizing enterocolitis in a full-term infant. Is acyclovir involved?].

N Montjaux-Régis¹, A Chanot, P Olivier

¹Unité de néonatologie, hôpital des Enfants, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 09, France. montjaux.n@chu-toulouse.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|October 16, 2007

Summary

Acyclovir, used to treat herpes, may pose risks to newborns. This case suggests a potential link between acyclovir prophylaxis and necrotizing enterocolitis in infants, warranting careful consideration of its use.

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Area of Science:

Neonatal Medicine
Pharmacology
Virology

Background:

Acyclovir is a widely used antiviral medication effective against herpes simplex virus infections.
Antiviral exposure during pregnancy and the neonatal period is generally considered safe.
Herpes simplex virus infections in pregnant individuals require careful management to prevent transmission to the neonate.

Observation:

A case of a full-term infant developing early-stage necrotizing enterocolitis is presented.
The infant received acyclovir prophylactically following in utero and postnatal exposure.
Maternal herpes genitalis and premature rupture of membranes were noted during pregnancy.

Findings:

The study explores acyclovir treatment in utero and postnatally as a potential contributing factor to necrotizing enterocolitis.
Necrotizing enterocolitis is a serious gastrointestinal condition affecting premature and newborn infants.
The safety profile of acyclovir in neonates requires further investigation in specific contexts.

Implications:

Acyclovir use in neonates, particularly for prophylaxis, should be carefully weighed against potential risks.
Further research is needed to elucidate the relationship between acyclovir and necrotizing enterocolitis.
Clinical guidelines may need revision regarding prophylactic acyclovir use in high-risk neonates.