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Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

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Related Experiment Video

Updated: Jul 10, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Auto-inflammatory fever syndromes.

Shai Padeh1, Yakov Berkun

  • 1Pediatric Rheumatology, Edmond & Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. padeh@012.net.il

Rheumatic Diseases Clinics of North America
|October 16, 2007
PubMed
Summary

Human autoinflammatory diseases are genetic disorders causing unprovoked inflammation. Recent advances have improved treatments and understanding, paving the way for better therapies.

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Human autoinflammatory diseases are a diverse group of genetically determined conditions.
  • Characterized by unprovoked inflammation without autoimmune or infectious triggers.
  • Recent decades show significant progress in understanding these disorders.

Purpose of the Study:

  • To summarize recent advances in understanding human autoinflammatory diseases.
  • To highlight the impact of these advances on therapeutic interventions.
  • To suggest future research directions for improved therapies.

Main Methods:

  • Review of recent scientific literature on human autoinflammatory diseases.
  • Analysis of therapeutic outcomes and molecular mechanisms.

Related Experiment Videos

Last Updated: Jul 10, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

  • Synthesis of current knowledge and future research perspectives.

    • Main Results:

    • Tremendous advances in understanding these genetic inflammatory diseases in the last decade.
    • Therapeutic interventions have improved both short-term and long-term morbidity.
    • Enhanced knowledge facilitates better and more targeted treatment strategies.

    Conclusions:

    • Continued research into molecular mechanisms will deepen understanding of autoinflammatory diseases.
    • This improved understanding is expected to yield more effective and targeted therapies.
    • Advances offer hope for better management and outcomes for patients.