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Published on: September 8, 2016
Functional crosslinked polymer particles synthesized by precipitation polymerization for liquid chromatography
R Perrier-Cornet1, V Héroguez, A Thienpont
1Laboratoire de Chimie des Polymères Organiques, CNRS, Université Bordeaux 1, Pessac 33607, France.
Journal of Chromatography. A
|October 16, 2007
Summary
Highly crosslinked functional polymer particles were synthesized for chromatography. These uniform chlorobenzyl particles exhibit tunable porosity and effectively separate polycyclic aromatic hydrocarbons in reversed-phase mode using only organic eluents.
Area of Science:
- Polymer Chemistry
- Chromatography Science
Background:
- Developing functional polymer particles with controlled properties is crucial for advanced separation techniques.
- Existing stationary phases may have limitations in separating challenging analytes like polycyclic aromatic hydrocarbons (PAHs).
Purpose of the Study:
- To synthesize highly crosslinked functional polymer particles with narrow size distribution.
- To investigate the influence of porogens on particle porosity (microporous to mesoporous).
- To evaluate the performance of these particles as a stationary phase in high-performance liquid chromatography (HPLC) for PAH separation.
Main Methods:
- Precipitation copolymerization of divinylbenzene, ethylene glycol dimethacrylate, and vinylbenzyl chloride.
- Modulation of particle porosity using various porogens (toluene, dodecanol, cyclohexanol, polypropylene glycol).
- Testing of synthesized particles as a stationary phase in reversed-phase HPLC for PAH separation.
Main Results:
- Uniform chlorobenzyl polymer particles with narrow size distribution were successfully synthesized.
- Particle porosity was successfully tuned from microporous to mesoporous by varying porogens.
- Effective separation of PAHs was achieved in reversed-phase mode using 100% organic eluents (methanol).
- The study investigated the impact of particle size, surface area, and packing on separation performance.
Conclusions:
- The synthesized functional polymer particles are effective stationary phases for PAH separation in HPLC.
- The ability to achieve separation with 100% organic eluents broadens chromatographic possibilities.
- Tunable porosity and controlled particle characteristics offer a versatile platform for chromatographic applications.
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