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The CUPDAY Study: prebiotic-probiotic milk product in 1-3-year-old children attending childcare centres

C W Binns1, A H Lee, H Harding

  • 1School of Public Health, Curtin University of Technology, Perth, Western Australia, Australia. c.binns@curtin.edu.au

Acta Paediatrica (Oslo, Norway : 1992)
|October 17, 2007
PubMed

Insights

Consuming a milk product with probiotics and prebiotics (CUPDAY Milk) significantly reduced diarrhoea incidence in young children attending daycare. This intervention led to a 20% decrease in days with four or more stools.

Area of Science:

  • Pediatric Nutrition
  • Gastroenterology
  • Microbiome Research

Background:

  • Diarrhoea is a common illness in children attending daycare centers, leading to significant healthcare costs and parental absence from work.
  • Probiotics and prebiotics are known to modulate the gut microbiota and may influence immune responses, potentially reducing infectious episodes.

Purpose of the Study:

  • To assess the efficacy of a specific milk product (CUPDAY Milk) containing both probiotics and prebiotics in reducing the incidence of diarrhoea among children in daycare settings.
  • To quantify the impact of this functional food intervention on diarrhoeal episodes defined by stool frequency.

Main Methods:

  • A randomized controlled trial was conducted with 496 children aged 1-3 years across 29 childcare centers in Perth, Australia.
  • The primary outcome measured was the number of days children experienced four or more stools.
  • Diarrhoeal rates were analyzed using Poisson regression on both 'intention to treat' and 'reduced' datasets.

Main Results:

  • No significant demographic differences were observed between the intervention and control groups.
  • The 'Cupday' milk group showed a statistically significant reduction in days with four or more stools.
  • An adjusted risk ratio of 0.82 (intention to treat) and 0.80 (reduced sample) indicated a 20% decrease in diarrhoeal days for children consuming the probiotic and prebiotic milk.

Conclusions:

  • A milk product fortified with probiotics and prebiotics effectively reduced the frequency of diarrhoeal episodes in young children attending daycare.
  • The findings support the use of synbiotic interventions in childcare settings to improve child health and reduce the burden of infectious diarrhoea.
Abstract

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