[Energy regulation of transmembrane potentials in liver cells during hypoxia]

The influence of oxygen tension on values of transmembrane potentials in rat liver cell was investigated. The membrane potential was assessed by the uptake TPP as was determined on the ion-selective electrode. Infusion of inhibitors oxidative phosphorylation and glycolysis to incubation medium caused depolarization on the mitochondrial, and, the plasma membranes of this cell. These and other experimental results suggest that there is an interaction between mitochondrial and cytosol pools of ATP, which determine steady-state values on transmembrane potential liver cell under hypoxia.