Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Combination of Proteogenomics with Peptide <i>De Novo</i> Sequencing Identifies New Genes and Hidden Posttranscriptional Modifications.

mBio·2019

Same author

How iMALDI can improve clinical diagnostics.

The Analyst·2018

Same author

pymzML v2.0: introducing a highly compressed and seekable gzip format.

Bioinformatics (Oxford, England)·2018

Same author

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

Translational psychiatry·2016

Same author

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.

Leukemia·2014

Same author

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

Journal of thrombosis and haemostasis : JTH·2013

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

[Functional proteome analysis of human platelets].

U Lewandrowski¹, R P Zahedi, J Moebius

¹Rudolf-Virchow-Zentrum für Experimentelle Biomedizin, Universität Würzburg.

Hamostaseologie

|October 17, 2007

Summary

This summary is machine-generated.

This study enhances platelet proteome characterization by identifying novel proteins and post-translational modifications, including phosphorylations and N-glycosylation sites. These findings offer new avenues for researching platelet function in thrombosis and hemostasis.

More Related Videos

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Jul 10, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Area of Science:

Biochemistry
Molecular Biology
Hematology

Context:

Platelets are crucial for hemostasis and thrombosis but their proteome remains incompletely understood.
Anucleated platelets are ideal for proteomic studies due to their simplified cellular structure.
Previous proteomic analyses have not fully captured the complexity of platelet proteins and their modifications.

Purpose:

To conduct comprehensive proteomic analyses of platelet subproteomes.
To identify novel proteins and post-translational modifications (PTMs) in platelets.
To lay the groundwork for future bioinformatic and functional studies of platelet biology.

Summary:

Proteomic analysis identified 489 previously undiscovered proteins in platelets.
Over 550 phosphorylation sites and 326 N-glycosylation sites were newly identified.
This expands the known platelet proteome and its modification landscape.

Impact:

Provides a significantly expanded dataset for platelet research.
Enables deeper functional characterization of platelet proteins and their PTMs.
Opens new avenues for understanding platelet roles in health and disease, particularly thrombosis and hemostasis.