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Rabies

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

Size and Structure of Viral Genomes

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Inhibitors Of Virion Release

Inhibitors Of Virion Release

Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...

Viral Structure

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

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Related Experiment Video

Updated: Jul 10, 2026

Quantitation of Rabies Virus in Various Bovine Brain Structures

Quantitation of Rabies Virus in Various Bovine Brain Structures

Published on: May 22, 2021

Structural aspects of rabies virus replication.

A A V Albertini¹, G Schoehn, W Weissenhorn

¹Unit for Virus Host Cell Interactions, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz, BP 181, 38042, Grenoble cedex 9, France.

Cellular and Molecular Life Sciences : CMLS

|October 17, 2007

Summary

This study reveals the atomic structure of the rabies virus nucleoprotein-RNA complex, crucial for viral transcription and replication. Understanding this structure aids in developing antiviral strategies against rabies virus.

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Last Updated: Jul 10, 2026

Quantitation of Rabies Virus in Various Bovine Brain Structures

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Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

Area of Science:

Virology
Structural Biology
Molecular Biology

Background:

Rabies virus is a negative-strand RNA virus.
Viral transcription and replication depend on the nucleoprotein (N)-RNA complex as a template.
The viral RNA-dependent RNA polymerase complex utilizes the N-RNA complex.

Purpose of the Study:

To discuss structural and functional aspects of rabies virus transcription and replication.
To analyze the atomic structure of a recombinant rabies virus N-RNA complex.
To provide a structural framework for understanding N-RNA interactions.

Main Methods:

Atomic structure determination of a recombinant rabies virus N-RNA complex.
Integration of existing biochemical data on N-RNA interactions.
Comparative analysis of rabies virus nucleoprotein structure with other related viruses.

Main Results:

The atomic structure of the rabies virus N-RNA complex was elucidated.
Biochemical data on N-RNA interactions were mapped onto the structural framework.
Structural similarities were identified between rabies virus nucleoprotein and those of other virus families.

Conclusions:

The atomic structure provides insights into the mechanisms of rabies virus transcription and replication.
Understanding N-RNA interactions is key to deciphering viral replication strategies.
Comparative structural analysis highlights potential conserved features among related RNA viruses.