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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
The non-coding region of BK subtype II viruses
Andi Krumbholz1, Peter Wutzler, Roland Zell
1Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans-Knoell-Str. 2, 07745 Jena, Germany. Andi.Krumbholz@med.uni-jena.de
Abstract:
Four BK virus (BKV) subtypes are distinguishable by serological and molecular methods. The type I followed by type IV represents the most common subtype. Subtypes II and III occur rarely. The complete sequence of a German subtype II isolate was determined. The lack of data on the structure of the non-coding region (NCR) of subtype II and III viruses prompted us to study this part of the genome in more detail. Sequence comparisons revealed that the archetypal configuration of subtype I strain WW seems to be predominant among BKV subtypes.
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