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Published on: March 30, 2018
Stage migration in dogs with lymphoma
Andrea B Flory1, Kenneth M Rassnick, Tracy Stokol
1Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Journal of Veterinary Internal Medicine
|October 18, 2007
Summary
Sensitive staging tests for canine lymphoma cause stage migration. However, the clinical stage did not predict treatment outcomes, highlighting the need for standardized lymphoma staging in dogs.
Area of Science:
- Veterinary Oncology
- Canine Medicine
Background:
- Lymphoma staging in dogs utilizes various diagnostic tests.
- Introduction of more sensitive methods leads to reclassification of disease stage.
Purpose of the Study:
- To investigate the impact of increasing staging test sensitivity on clinical stage migration in dogs with lymphoma.
- To determine if different staging methods affect prognosis prediction.
Main Methods:
- Fifty-nine dogs with lymphoma were staged using five different groupings of diagnostic tests (A-E), ranging in sensitivity.
- Dogs received doxorubicin-based chemotherapy protocols.
Main Results:
- Stage migration occurred between most staging methods, except between D and E.
- Clinical stage, regardless of the method used, did not predict remission rates, duration, or survival.
Conclusions:
- The study highlights significant stage migration in canine lymphoma due to varying diagnostic test combinations.
- Standardized lymphoma staging methods are crucial for accurate comparisons and prognosis in dogs.
