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Determining the source of fetal adiponectin.
Shali Mazaki-Tovi1, Hannah Kanety, Clara Pariente
1Department of Obstetrics and Gynecology and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
The Journal of Reproductive Medicine
|October 18, 2007
Summary
High cord blood adiponectin levels originate from fetal tissues, not maternal or placental sources. This finding clarifies the source of elevated adiponectin in newborns.
Area of Science:
- Endocrinology
- Neonatal Physiology
- Metabolic Research
Background:
- Adiponectin is a key adipokine involved in glucose and lipid metabolism.
- Elevated adiponectin levels are observed in cord blood at birth.
Purpose of the Study:
- To investigate the origin of high adiponectin concentrations in cord blood.
- To determine if maternal, placental, or fetal compartments contribute to cord blood adiponectin.
Main Methods:
- Compared serum adiponectin levels in newborns and their mothers.
- Analyzed cord blood adiponectin at delivery and 4 days postpartum.
- Assessed adiponectin mRNA expression in human placental tissues using RT-PCR.
Main Results:
- Cord blood adiponectin levels were significantly higher than maternal levels and showed no correlation.
- Adiponectin mRNA was not detected in placental tissues.
- Postpartum serum adiponectin levels in newborns did not significantly differ from cord blood levels.
Conclusions:
- Maternal and placental sources do not contribute to high cord blood adiponectin.
- Fetal tissues are the likely source of elevated adiponectin in the umbilical cord.
- This study elucidates the fetal origin of cord blood adiponectin.
