Are babies getting bigger? Secular trends in fetal growth in Israel--a retrospective hospital-based cohort study

Shmuel Davidson1, Aviva Litwin, Dan Peleg

  • 1Department of Neonatology, Women's Comprehensive Health Care Center, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel. shmueld@clalit.org.il

Insights

Israeli infants are growing larger and longer, contrary to global trends. This study found increased birth weight and length, with a simultaneous decrease in preterm births, suggesting improved prenatal care.

Area of Science:

  • Neonatal anthropometry
  • Perinatal epidemiology
  • Secular trends in infant growth

Background:

  • Developed countries report a paradoxical trend of increasing preterm births and decreasing low birth weights over 25 years.
  • This study investigates secular trends in Israeli neonates, including birth weight, length, and head circumference.

Purpose of the Study:

  • To determine if the paradoxical trend of increasing preterm births and decreasing low birth weights is observed in Israeli neonates.
  • To analyze secular trends in crown-heel length and head circumference among Israeli infants.

Main Methods:

  • A hospital-based historic cohort study design was employed.
  • Anthropometric data from 32,062 infants born at Rabin Medical Center between 1986 and 2004 were analyzed.
  • Data were collected from the hospital's computerized registry and compared across three time periods: 1986-1987, 1994-1996, and 2003-2004.

Main Results:

  • Significant increases in mean birth weight (41 g), crown-heel length (1.3 cm), and head circumference (0.1 cm) were observed from 1986 to 2004 (P < 0.001).
  • The proportion of preterm, very preterm, extremely preterm, low birth weight, and very low birth weight infants significantly decreased over time (P < 0.002).
  • Term infants showed increased length and head circumference, while moderately preterm infants showed increased weight and length.

Conclusions:

  • Infants born at Rabin Medical Center, both term and preterm, have shown significant increases in size (weight, length, head circumference) over time.
  • This growth trend is associated with a decrease in the proportion of preterm births, contrasting with trends in other developed countries.
  • These findings may indicate improvements in antenatal care and maternal determinants influencing infant growth and development.
Abstract

Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Population Growth00:57

Population Growth

Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.However, realistic environmental conditions limit the number of...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...