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Updated: Jul 10, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Published on: July 4, 2011

[Sodium determination in biological fluids].

J-P Cristol¹, B Balint, B Canaud

¹Laboratoire de biochimie, CHU de/Montpellier, Hôpital Lapeyronie, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France. jp-cristol@chu-montpellier.fr

Nephrologie & Therapeutique

|November 21, 2007

Summary

This summary is machine-generated.

Serum sodium (Na) determination methods impact results. Direct potentiometry avoids pseudohyponatremia interference seen with diluted samples in flame photometry or indirect potentiometry.

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Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Functional Characterization of Na⁺/H⁺ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

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Last Updated: Jul 10, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

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Published on: July 4, 2011

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Functional Characterization of Na⁺/H⁺ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

Area of Science:

Clinical Chemistry
Analytical Chemistry
Nephrology

Context:

Electrolyte disorders are common in nephrology and intensive care.
Sodium determination is a routine biochemistry laboratory test.
Multiple analytical methods exist for serum sodium (Na) measurement.

Purpose:

To compare different serum sodium measurement methods.
To highlight discrepancies arising from methodological differences.
To explain pseudohyponatremia in relation to sample handling.

Summary:

Flame photometry and indirect potentiometry dilute samples, potentially causing pseudohyponatremia in decreased plasma water.
Direct potentiometry measures sodium activity in plasma water without dilution, avoiding pseudohyponatremia interference from hyperlipidemia or paraproteinemia.
Analytical performances are satisfactory across all methods in normal and pathological ranges.

Impact:

Understanding methodological differences is crucial for interpreting discrepant sodium results.
Direct potentiometry offers an advantage in accurately measuring sodium in specific conditions.
Ensures accurate electrolyte disorder diagnosis and patient management.