The effects of ABCB1 3'-untranslated region variants on mRNA stability

Jason M Gow1, Leslie W Chinn, Deanna L Kroetz

  • 1The Department of Biopharmaceutical Sciences, University of California, San Francisco, California 94158-2911, USA.

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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