Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolone disposition in the elderly. Practical implications.

I Nilsson-Ehle1, B Ljungberg

  • 1Department of Infectious Diseases, University Hospital, Lund, Sweden.

Drugs & Aging
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

Urologic oncology·2017
Same author

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2015
Same author

[Not Available].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
Same author

Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology--discrimination of normal human prostate tissues ex vivo.

Journal of medical engineering & technology·2015
Same author

[Ischemia is not an independent predictive factor of chronic renal failure after partial nephrectomy in a solitary kidney in patients without pre-operative renal insufficiency].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2014
Same author

Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study.

International journal of cancer·2013

Elderly individuals require careful fluoroquinolone dosing due to age-related pharmacokinetic changes. Dosage adjustments are crucial for antibiotics like ofloxacin and ciprofloxacin to ensure safety and efficacy in older patients.

Area of Science:

  • Pharmacology
  • Geriatrics
  • Infectious Diseases

Background:

  • Fluoroquinolones are commonly prescribed antibiotics for infections in the elderly.
  • Aging significantly impacts drug pharmacokinetics, often requiring dosage adjustments.

Purpose of the Study:

  • To review the pharmacokinetic changes of fluoroquinolones in elderly individuals.
  • To provide guidance on appropriate fluoroquinolone dosing in geriatric populations.

Main Methods:

  • Review of existing literature on fluoroquinolone pharmacokinetics in the elderly.
  • Analysis of age-related changes in drug absorption, distribution, metabolism, and excretion.

Main Results:

  • Ofloxacin elimination is slower in the elderly, necessitating dose reduction.

Related Experiment Videos

  • Ciprofloxacin exhibits increased oral bioavailability in older adults, suggesting lower oral doses.
  • Renal clearance of fluoroquinolones generally decreases with age.
  • Data on other fluoroquinolones (norfloxacin, enoxacin, pefloxacin) in the elderly is limited.

    • Conclusions:

    • Dose adjustments for fluoroquinolones are often necessary in the elderly due to altered pharmacokinetics, particularly renal function decline.
    • Caution is advised when prescribing fluoroquinolones to the elderly due to potential adverse effects and drug interactions.