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Updated: Jul 10, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Advances in stereotactic radiosurgery in the treatment of pituitary adenomas
Marc Mayberg1, Sandra Vermeulen
1Neurological Surgery, Swedish Neuroscience Institute, Seattle, Washington 98122, USA. Marc.Mayberg@swedish.org
Purpose Of Review:
Stereotactic radiosurgery has become the preferred radiation treatment modality for secreting and nonsecreting pituitary adenomas, although randomized studies comparing delivery systems, fractionation and dose have not been performed.
Recent Findings:
The technical achievement of radiosurgery delivery systems has minimized the radiation dose to surrounding normal tissue compared with external beam radiotherapy. With a reduction in acute and chronic side effects, the total dose to abnormal tissue can be increased allowing for greater tumor control.
Summary:
The radiobiology, control rates and normal tissue tolerances of stereotactic radiosurgery in the treatment of pituitary adenomas is reviewed.
