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Updated: Jul 10, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Cyclical Cushing's syndrome: an update.

Karen R Mullan¹, A Brew Atkinson, Brian Sheridan

¹Regional Centre for Endocrinology andDiabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.

Current Opinion in Endocrinology, Diabetes, and Obesity

|October 18, 2007

Summary

Cyclical hypercortisolism, once rare, is now increasingly recognized. Understanding its fluctuating cortisol levels is crucial for accurate diagnosis and management to avoid serious clinical consequences.

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Area of Science:

Endocrinology
Internal Medicine

Background:

Cyclical Cushing's syndrome, characterized by rhythmic fluctuations in cortisol production, was previously considered rare.
Increasing recognition highlights its prevalence and diagnostic challenges.

Purpose of the Study:

To review the features of cyclical hypercortisolism.
To discuss diagnostic and management strategies for this condition.

Main Methods:

Review of existing literature on cyclical hypercortisolism.
Discussion of pathophysiological mechanisms and centrally acting drug effects.
Presentation of diagnostic criteria and biochemical tools for detecting cyclical patterns.

Main Results:

Cyclical hypercortisolism presents with fluctuating cortisol levels and associated signs/symptoms.
Misdiagnosis can lead to errors in diagnosis, differential diagnosis, and treatment assessment.
The pathophysiology remains incompletely understood, though recent insights exist.

Conclusions:

Cyclical Cushing's syndrome is more common than previously thought.
Early recognition and appropriate diagnostic tools are essential to prevent misdiagnosis and clinical errors.
Effective management strategies are crucial for this subgroup of hypercortisolism patients.