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Turing patterns inside cells.

Damián E Strier1, Silvina Ponce Dawson

  • 1Service de Chimie Physique and Center for Nonlinear Phenomena and Complex Systems, Université Libre de Bruxelles, Brussels, Belgium.

Plos One
|October 18, 2007
PubMed
Summary
This summary is machine-generated.

A new model shows phosphofructokinase (PFK) can create Turing patterns within cells. These patterns, crucial for cell division, have a length scale smaller than a cell, regulated by enzyme concentration and glycolytic flux.

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Area of Science:

  • Cellular biology
  • Biochemistry
  • Systems biology

Background:

  • Concentration gradients are essential for cellular processes like division and morphogenesis.
  • The glycolytic pathway, vital for cellular energy, exhibits oscillations regulated by enzymes like phosphofructokinase (PFK).

Purpose of the Study:

  • To investigate Turing pattern formation in a model of the phosphofructokinase (PFK) enzymatic step within the glycolytic pathway.
  • To determine if PFK activity can generate spatial patterns with cell-intrinsic length scales.

Main Methods:

  • Developed a computational model of the PFK-catalyzed reaction in glycolysis.
  • Assumed equal diffusion coefficients for ATP and ADP.
  • Analyzed pattern formation with parameter values consistent with experimental data on glycolytic oscillations.

Main Results:

  • The PFK model demonstrated Turing pattern formation with an intrinsic length scale smaller than a typical cell size.
  • Enzyme concentration and glycolytic flux were identified as key regulators of these patterns.
  • This represents the first closed model of Turing patterns in a core metabolic pathway with experimentally compatible parameters.

Conclusions:

  • Turing patterns can emerge from a vital metabolic step (PFK) within cellular environments.
  • These patterns offer a potential mechanism for integrating biochemical and mechanical signals during cell division.
  • The model provides a framework for understanding pattern formation in cellular metabolism and its role in cell cycle regulation.