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Updated: Jul 10, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Why cancer and inflammation?

Seth Rakoff-Nahoum¹

¹Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. seth.rakoff-nahoum@yale.edu

The Yale Journal of Biology and Medicine

|October 18, 2007

Summary

Cancer development involves genetic changes and tumor microenvironment factors. This review explores the link between inflammation and cancer, focusing on tissue homeostasis and repair roles.

Area of Science:

Oncology
Immunology
Cell Biology

Background:

Cancer cells acquire genetic mutations for uncontrolled growth and survival.
Tumor progression relies on non-cancerous cells within the tumor microenvironment.
Inflammation is a known factor associated with cancer development.

Purpose of the Study:

To review the relationship between cancer and inflammation.
To explore how inflammation in tissue homeostasis and repair relates to cancer.
To provide a framework for understanding the cancer-inflammation connection.

Main Methods:

Literature review and synthesis of existing research.
Discussion of the role of inflammation in physiologic processes.
Analysis of the interplay between inflammatory responses and cancer development.

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Last Updated: Jul 10, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Main Results:

Genetic changes in cancer cells are necessary but not sufficient for tumor development.
The tumor microenvironment, including inflammation, plays a crucial role in tumor promotion and progression.
Understanding inflammation's role in tissue repair offers insights into its connection with cancer.

Conclusions:

The relationship between cancer and inflammation is complex and bidirectional.
Physiologic roles of inflammation in tissue homeostasis and repair are relevant to cancer.
A framework integrating inflammation's normal functions may clarify its role in cancer.