Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnancy and multiple sclerosis.

Maria K Houtchens1

  • 1Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, Brookline, Massachusetts 02445, USA. mhoutchens@partners.org

Seminars in Neurology
|October 18, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurological involvement and pregnancy outcomes in autoimmune disease: mechanisms, clinical implications, and research gaps.

Rheumatology international·2026
Same author

Expert Opinion on Age-Related Sex Hormone Changes and Hypogonadism in People With Multiple Sclerosis: A Delphi Consensus Program.

Neurology. Clinical practice·2026
Same author

Cladribine Is Associated With Stable Cortical Gray Matter Lesion Burden in Multiple Sclerosis: A 7T MRI Study.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2025
Same author

A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States: PREG-MS.

Neurology. Clinical practice·2025
Same author

Practical Considerations for Managing Pregnancy in Patients With Multiple Sclerosis: Dispelling the Myths.

Neurology. Clinical practice·2024
Same author

Pregnancy and reproductive health in women with multiple sclerosis: an update.

Current opinion in neurology·2024
Same journal

Isolated Cranial Tremors: A Reappraisal.

Seminars in neurology·2026
Same journal

Dystonia and Tremor.

Seminars in neurology·2026
Same journal

Pendular nystagmus and oculopalatal tremor.

Seminars in neurology·2026
Same journal

Sanjay Pandey, MBBS, MD, DNB, DM, FIAN, and Aasef Shaikh, MD, PhD.

Seminars in neurology·2026
Same journal

Tremor.

Seminars in neurology·2026
Same journal

Carotid Disease.

Seminars in neurology·2026
See all related articles

Pregnancy in women with multiple sclerosis (MS) does not appear to negatively impact disease course or long-term outcomes. Management strategies for MS during pregnancy are crucial for patient well-being.

Area of Science:

  • Neurology
  • Immunology
  • Reproductive Medicine

Background:

  • Multiple sclerosis (MS) is a central nervous system autoimmune disease primarily affecting women of childbearing age.
  • Pregnancy-related issues are critical for MS patients and their physicians, necessitating a review of current knowledge.

Purpose of the Study:

  • To discuss the immunological and clinical effects of pregnancy on MS.
  • To review clinical outcomes from Pregnancy in Multiple Sclerosis (PRIMS) trials.
  • To evaluate the safety and efficacy of MS treatments during pregnancy and lactation.

Main Methods:

  • Review of existing literature on pregnancy and MS.
  • Analysis of data from the Pregnancy in Multiple Sclerosis (PRIMS) trials.
  • Examination of safety and efficacy data for immunomodulatory and symptomatic MS treatments in pregnant/lactating women.

Related Experiment Videos

  • Review of estrogen-based MS therapies.

    • Main Results:

    • Pregnancy does not appear to be associated with adverse outcomes in multiple sclerosis patients.
    • Some evidence suggests potential beneficial effects of pregnancy on MS, though long-term prospective data are limited.
    • Long-term relapse rates and disability progression in MS patients are not significantly affected by pregnancy.

    Conclusions:

    • Pregnancy is generally not associated with adverse outcomes for women with multiple sclerosis.
    • Immunomodulatory or immunosuppressive agents are not routinely recommended during pregnancy for MS management.
    • Further research with long-term prospective data is needed to fully understand pregnancy's effects on MS.