Related Experiment Video
Updated: Jul 10, 2026
02:26
Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
[Apomorphine in off state--clinical experience].
Monika Rudzińska1, Andrzej Szczudlik
1Szpital Uniwersytecki w Krakowie. rudzinsk@neuro.cm-uj.krakow.pl
Neurologia I Neurochirurgia Polska
|October 19, 2007
Summary
Apomorphine, a dopamine agonist, effectively reduces off-time in Parkinson's disease patients. While offering rapid relief, its use is limited by side effects and cost.
Area of Science:
- Pharmacology
- Neuroscience
Context:
- Parkinson's disease management
- Dopamine receptor agonism
Purpose:
- Evaluate apomorphine's efficacy and safety in Parkinson's disease
- Explore alternative administration routes
Summary:
- Apomorphine, a potent dopamine agonist, significantly reduces "off" periods in advanced Parkinson's disease.
- Subcutaneous administration is common, though other routes are explored; oral use is not recommended.
- Pre-treatment with antiemetics is advised to mitigate side effects like nausea and vomiting.
Impact:
- Apomorphine offers rapid antiparkinsonian effects comparable to levodopa.
- Adverse events are generally mild but can be route-specific.
- Wider application is hindered by cost and administration challenges, despite proven efficacy.
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