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Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes
B A Brooks1, B Franjic, C R Ban
1Diabetes Centre, Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. belinda@email.cs.nsw.gov.au
Diabetes, Obesity & Metabolism
|October 19, 2007
Summary
Diabetic cardiomyopathy involves early diastolic dysfunction (DD). While microvascular function is linked to DD in type 2 diabetes, connective tissue growth factor (CTGF) is not strongly associated.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Diabetic cardiomyopathy is a growing concern, with early diastolic dysfunction (DD) poorly understood.
- Potential causes include microvessel dysfunction and profibrotic factors like connective tissue growth factor (CTGF).
Purpose of the Study:
- To investigate the association between microvascular dysfunction and CTGF levels with subclinical DD in type 2 diabetes patients.
Main Methods:
- Compared 40 type 2 diabetes patients with 20 controls.
- Assessed microvascular function via laser Doppler velocimetry (acetylcholine and sodium nitroprusside tests).
- Measured plasma CTGF levels using Western immunoblotting.
Main Results:
- Diabetic patients showed more DD by tissue Doppler indices (E/E', E'/A') than controls.
- Both endothelium-dependent and independent microvascular responses were reduced in diabetes.
- No significant correlation was found between CTGF levels and DD parameters or microvascular function.
Conclusions:
- Microvascular function is significantly associated with DD in type 2 diabetes.
- Endothelial dysfunction and CTGF do not strongly predict subclinical DD.
- Other factors likely contribute to the early development of cardiac DD in type 2 diabetes.
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