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Endothelium-derived vasoactive mediators and renal glomerular function.

B J Ballermann1, P A Marsden

  • 1Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|December 1, 1991
PubMed
Summary
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Glomerular endothelial cells release endothelium-derived relaxation factor (EDRF) and endothelin-1, influencing kidney blood flow by regulating mesangial cell tone.

Area of Science:

  • Nephrology
  • Vascular Biology
  • Cellular Physiology

Background:

  • Glomerular endothelial and mesangial cells are closely apposed, suggesting cell-cell interactions.
  • Endothelial cells produce mediators affecting vascular smooth muscle tone.

Purpose of the Study:

  • To investigate if glomerular endothelial cells produce endothelium-derived relaxation factor (EDRF) and endothelin-1.
  • To determine the regulation of these factors by calcium-mobilizing agonists.

Main Methods:

  • Established pure cultures of glomerular endothelial cells in vitro.
  • Characterized cells using Factor VIII antigen, angiotensin I converting enzyme, and acetylated LDL uptake.
  • Measured cytosolic calcium, EDRF, and endothelin-1 production in response to agonists.

Related Experiment Videos

Main Results:

  • Glomerular endothelial cells produced a mediator similar to EDRF, increasing mesangial cell cGMP levels.
  • Calcium-mobilizing agonists stimulated both EDRF and endothelin-1 release.
  • Endothelin-1 gene transcription was activated by these agonists.

Conclusions:

  • Glomerular endothelial cells produce EDRF and endothelin-1.
  • These factors may regulate glomerular hemodynamics via mesangial cell contractile tone.
  • Local release of these mediators plays a role in kidney function regulation.