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Updated: Jul 10, 2026
07:50
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
Ischemia-reperfusion and immediate T cell responses
Yanfei Huang1, Hamid Rabb, Karl L Womer
1Division of Nephrology, Johns Hopkins University School of Medicine, Ross 965, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Cellular Immunology
|October 19, 2007
Summary
Ischemia-reperfusion injury (IRI) involves complex inflammation. This review highlights T cells
Area of Science:
- Immunology
- Pathophysiology
- Organ Transplantation
Background:
- Ischemia-reperfusion injury (IRI) pathogenesis is complex.
- Inflammation, involving leukocytes, adhesion molecules, chemokines, and cytokines, is crucial in IRI.
- Emerging evidence implicates T cells in IRI across various organs.
Purpose of the Study:
- To review recent evidence on the role of T cells in IRI.
- To advance the understanding of T cell involvement in IRI pathogenesis.
- To explore the potential of immunotherapeutic strategies for IRI.
Main Methods:
- Review of existing literature and animal models.
- Analysis of T cell subset functions in IRI.
- Synthesis of data on T cell-mediated injury and protection.
Main Results:
- T cells act as key mediators in IRI.
- Different T cell subsets exhibit divergent roles in IRI phases.
- Evidence supports T cell involvement in both renal and extra-renal IRI.
Conclusions:
- T cells play a significant and complex role in IRI.
- Understanding T cell dynamics in IRI can inform therapeutic strategies.
- Immunotherapy targeting T cells holds promise for IRI prevention and treatment.
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