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Endometrial volume as predictor of malignancy in women with postmenopausal bleeding
G M Mansour1, I K I El-Lamie, M A El-Kady
1Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt.
Objective:
To assess endometrial volume as a predictor of endometrial malignancy in women with postmenopausal bleeding.
Methods:
Endometrial volume was measured by virtual organ computer-aided analysis in 170 women with postmenopausal bleeding, and histopathologic results of endometrial biopsies were obtained for all. A group of 100 women without postmenopausal bleeding was used for control.
Results:
There were 90 cases of benign disease, 53 cases of atypia, and 27 cases of endometrial cancers in the study group. Whereas endometrial thickness was 9.61+/-5.12 mm (range, 5-20 mm) and endometrial volume was 3+/-1.1 mL (range, 1.8-5.4 mL) in women with atypia or cancer, they were 4.87+/-3.43 mm (range, 2-8 mm) and 1.52+/-0.82 (range, 0.6-2.2 mL), respectively, in women with benign disease. In the control group, endometrial volume was 1.15+/-0.14 mL (range, 0.6-1.3 mL). Volume was more sensitive than thickness for predicting malignancy, and a cutoff value of 1.35 mL was found to provide the best sensitivity.
Conclusion:
An endometrial volume of 1.35 mL or greater may predict malignancy in women with postmenopausal bleeding.
