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Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia

Tamara Djurić1, Maja Zivković, Aleksandra Stanković

  • 1Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, 11000 Belgrade, Serbia. tamariska@vin.bg.ac.yu

Journal of the Neurological Sciences
|October 19, 2007
PubMed

Insights

The MMP-3 6A/6A genotype is linked to increased Multiple Sclerosis Severity Score (MSSS) in Serbian patients. This finding suggests a potential role for MMP-3 in MS progression and warrants consideration in patient follow-up.

Area of Science:

  • Neuroimmunology
  • Genetics
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) are enzymes crucial for extracellular matrix remodeling.
  • MMPs are implicated in central nervous system (CNS) inflammation, blood-brain barrier disruption, and myelin degradation.
  • The specific role of MMP-3 gene polymorphism in Multiple Sclerosis (MS) susceptibility and severity requires further investigation.

Purpose of the Study:

  • To investigate the association between the MMP-3 5A/6A gene polymorphism and susceptibility or severity of MS in a Serbian cohort.
  • To analyze genotype frequencies in MS patients and healthy controls.
  • To evaluate the correlation between MMP-3 genotypes and clinical parameters like the Multiple Sclerosis Severity Score (MSSS).

Main Methods:

  • Genotyping of the MMP-3 5A/6A polymorphism in 184 MS patients (150 RRMS, 34 SPMS) and 236 controls from Serbia.
  • Statistical analysis to compare genotype distributions between cases and controls.
  • Analysis of MSSS values in relation to MMP-3 genotypes in patients with bout onset MS.

Main Results:

  • No significant difference in MMP-3 5A/6A genotype frequencies was observed between MS patients and controls.
  • Patients with the MMP-3 6A/6A genotype exhibited significantly higher mean MSSS values compared to carriers of the 5A allele in bout onset MS.
  • Statistical significance was confirmed using ANCOVA and Scheffe post-hoc tests (p=0.01).

Conclusions:

  • The MMP-3 6A/6A genotype is associated with increased disease severity in MS patients, as indicated by higher MSSS values.
  • These findings suggest that MMP-3 polymorphism may influence MS progression and should be considered in patient management.
  • Further research into the complex roles of MMPs and their inhibitors in MS pathology and potential regeneration is warranted.

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